Antibiotics

Antibiotics Reaction Overview

In common usage, an antibiotic (from the Ancient Greek: ἀντί – anti, “against”, and βίος – bios, “life”) is a substance or compound that kills bacteria or inhibits their growth. Antibiotics belong to the broader group of antimicrobial compounds, used to treat infections caused by microorganisms, including fungi and protozoa.

The term “antibiotic” was coined by Selman Waksman in 1942 to describe any substance produced by a microorganism that is antagonistic to the growth of other microorganisms in high dilution. This original definition excluded naturally occurring substances that kill bacteria but are not produced by microorganisms (such as gastric juice and hydrogen peroxide) and also excluded syntheticantibacterial compounds such as the sulfonamides. Many antibiotics are relatively small moleculeswith a molecular weight less than 2000.

With advances in medicinal chemistry, most antibiotics are now semisynthetic—modified chemically from original compounds found in nature, as is the case with beta-lactams (which include thepenicillins, produced by fungi in the genus Penicillium, the cephalosporins, and the carbapenems). Some antibiotics are still produced and isolated from living organisms, such as theaminoglycosides, and others have been created through purely synthetic means: the sulfonamides, the quinolones, and the oxazolidinones. In addition to this origin-based classification into natural, semisynthetic, and synthetic, antibiotics may be divided into two broad groups according to their effect on microorganisms: Those that kill bacteria are bactericidal agents, whereas those that only impair bacterial growth are known as bacteriostatic agents.